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Article

Association between MGMT promoter hypermethylation and p53 mutation in glioblastoma.

Cancer investigation - 1 Oct 2009

Shamsara Jamal, Sharif Samaneh, Afsharnezhad Sima, Lotfi Marzieh, Raziee Hamid Reza, Ghaffarzadegan Kamran, Moradi Afshin, Rahighi Saeed, Behravan Javad

Abstract excerpt

O(6)-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that removes alkyl groups from the O(6) position of guanine. MGMT is transcriptionally silenced by promoter hypermethylation in several human neoplasia. We used methylation-specific PCR (MSP) to analyze the MGMT promoter methylation status of 50 glioblastoma tumors. Hypermethylation was detected in 24 of 50 (48%) samples. We also analyzed...

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Identifiers

PMID: 19544111
DOI: 10.1080/07357900902783211

Genes

MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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