Article
TP53 promoter methylation in primary glioblastoma: relationship with TP53 mRNA and protein expression and mutation status.
DNA and cell biology - 1 Apr 2014
Jesionek-Kupnicka Dorota, Szybka Malgorzata, Malachowska Beata, Fendler Wojciech, Potemski Piotr, Piaskowski Sylwester, Jaskolski Dariusz, Papierz Wielislaw, Skowronski Wieslaw, Och Waldemar, Kordek Radzislaw, Zawlik Izabela
Abstract excerpt
Reduced expression of TP53 by promoter methylation has been reported in several neoplasms. It remains unclear whether TP53 promoter methylation is associated with reduced transcriptional and protein expression in glioblastoma (GB). The aim of our work was to study the impact of TP53 methylation a...
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