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Article

Relevance of MSP assay for the detection of MGMT promoter hypermethylation in glioblastomas

1 Jan 1992

Abstract excerpt

O6-Methylguanine-DNA methyltransferase (MGMT) promoter hypermethylation has recently emerged as a powerful determinant of chemotherapy sensitivity in glioblastomas. To adapt such an important epigenetic biomarker to routine application in the clinical setting, we validated the conventionally used methylation-specific polymerase chain reaction (MSP) assay for its relevance in the determination of MGMT methylation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18695875
DOI: 10.3892/ijo_00000029

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