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Article

11-β hydroxysteroid type 1 knockout mice display an antidepressant-like phenotype in the forced swim test.

Acta neuropsychiatrica - 1 Feb 2016

Slattery David A, Uzunov Doncho P, Cryan John F

Abstract excerpt

OBJECTIVE: 11β-dehydroxysteroid dehydrogenase (HSD) types 1 and 2, enzymes are involved in the activation and inactivation of glucocorticoids in vivo, respectively. Indirect evidence implicates two enzymes in the aetiology of depression but no study has directly assessed the potential role of 11 β-HSD1 in animal tests. METHODS: We assessed 11 β-HSD1 knockout mice in the forced swim test (FST), tail suspension...

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Source

Identifiers

PMID: 26400016
DOI: 10.1017/neu.2015.50

Genes

FST
TST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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