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Article

Impact of disruption of secondary binding site S2 on dopamine transporter function.

Journal of neurochemistry - 1 Sept 2016

Zhen Juan, Reith Maarten E A

Abstract excerpt

The structures of the leucine transporter, drosophila dopamine transporter, and human serotonin transporter show a secondary binding site (designated S2 ) for drugs and substrate in the extracellular vestibule toward the membrane exterior in relation to the primary substrate recognition site (S1 ). The present experiments are aimed at disrupting S2 by mutating Asp476 and Ile159 to Ala. Both mutants displayed a...

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Identifiers

PMID: 27315582
DOI: 10.1111/jnc.13704
PMCID: PMC4996714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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