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Article

Mutations of Human DopamineTransporter at Tyrosine88, Aspartic Acid206, and Histidine547 Influence Basal and HIV-1 Tat-inhibited Dopamine Transport.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology - 1 Dec 2021

Quizon Pamela M, Yuan Yaxia, Zhu Yike, Zhou Yi, Strauss Matthew J, Sun Wei-Lun, Zhan Chang-Guo, Zhu Jun

Abstract excerpt

HIV-1 transactivator of transcription (Tat) has a great impact on the development of HIV-1 associated neurocognitive disorders through disrupting dopamine transmission. This study determined the mutational effects of human dopamine transporter (hDAT) on basal and Tat-induced inhibition of dopamine transport. Compared to wild-type hDAT, the maximal velocity (Vmax) of [3H]dopamine uptake was decreased in D381L and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33537927
DOI: 10.1007/s11481-021-09984-5
PMCID: PMC8329121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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