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Article

The N terminus of monoamine transporters is a lever required for the action of amphetamines.

The Journal of biological chemistry - 2 Apr 2010

Sucic Sonja, Dallinger Stefan, Zdrazil Barbara, Weissensteiner René, Jørgensen Trine N, Holy Marion, Kudlacek Oliver, Seidel Stefan, Cha Joo Hwan, Gether Ulrik, Newman Amy H, Ecker Gerhard F, Freissmuth Michael, Sitte Harald H

Abstract excerpt

The serotonin transporter (SERT) terminates neurotransmission by removing serotonin from the synaptic cleft. In addition, it is the site of action of antidepressants (which block the transporter) and of amphetamines (which induce substrate efflux). We explored the functional importance of the N terminus in mediating the action of amphetamines by focusing initially on the highly conserved threonine residue at...

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Identifiers

PMID: 20118234
DOI: 10.1074/jbc.M109.083154
PMCID: PMC2856298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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