Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder.

doi:10.1523/JNEUROSCI.5094-09.2010

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Article

Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Apr 2010

Bowton Erica, Saunders Christine, Erreger Kevin, Sakrikar Dhananjay, Matthies Heinrich J, Sen Namita, Jessen Tammy, Colbran Roger J, Caron Marc G, Javitch Jonathan A, Blakely Randy D, Galli Aurelio

Abstract excerpt

The neurotransmitter dopamine (DA) modulates brain circuits involved in attention, reward, and motor activity. Synaptic DA homeostasis is primarily controlled via two presynaptic regulatory mechanisms, DA D(2) receptor (D(2)R)-mediated inhibition of DA synthesis and release, and DA transporter (DAT)-mediated DA clearance. D(2)Rs can physically associate with DAT and regulate DAT function, linking DA release and...

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Identifiers

PMID: 20427663
DOI: 10.1523/JNEUROSCI.5094-09.2010
PMCID: PMC2881830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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