Article
N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux.
PLoS biology - 1 Mar 2004
Khoshbouei Habibeh, Sen Namita, Guptaroy Bipasha, Johnson L 'Aurelle, Lund David, Gnegy Margaret E, Galli Aurelio, Javitch Jonathan A
Abstract excerpt
Amphetamine (AMPH) elicits its behavioral effects by acting on the dopamine (DA) transporter (DAT) to induce DA efflux into the synaptic cleft. We previously demonstrated that a human DAT construct in which the first 22 amino acids were truncated was not phosphorylated by activation of protein kinase C, in contrast to wild-type (WT) DAT, which was phosphorylated. Nonetheless, in all functions tested to date,...
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