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Mitochondrial transcription factors TFA, TFB1 and TFB2: a search for DNA variants/haplotypes and the risk of cardiac hypertrophy.

Disease markers - 1 Jan 2008

Alonso-Montes Cristina, Castro Mónica G, Reguero Julián R, Perrot Andreas, Ozcelik Cemil, Geier Christian, Posch Maximilian G, Morís César, Alvarez Victoria, Ruiz-Ortega Marta, Coto Eliecer

Abstract excerpt

Mitochondrial transcription factors mtTFA, mtTFB1 and mtTFB2 are required for the replication of mitochondrial DNA (mtDNA), regulating the number of mtDNA copies. Mice with a mtTFA deletion showed a reduced number of mtDNA copies, a reduction in respiratory chain activity, and a characteristic dilated cardiomyopathy. DNA variants in these genes could be involved in the risk for cardiac hypertrophy (HCM). We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19096125
DOI: 10.1155/2008/575323
PMCID: PMC3827797

Genes

TFAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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