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Article

Mutational screening of the mitochondrial transcription factors B1 and B2 (TFB1M and TFB2M) in Parkinson's disease.

Parkinsonism & related disorders - 1 Jul 2009

Sánchez-Ferrero Elena, Coto Eliecer, Blázquez Marta, Ribacoba René, Guisasola Luis M, Salvador Carlos, Alvarez Victoria

Abstract excerpt

Mitochondrial dysfunction has been implicated in Parkinson's disease (PD). The nuclear encoded transcription factors A, B1 and B2 are essential for mitochondrial DNA replication. Sequence variants at the genes encoding TFAM, TFB1M and TFB2M could contribute to the risk of developing PD. Here, we searched for TFB1M and TFB2M nucleotide variants in a cohort of PD-patients (n=300) and healthy controls (n=200) from...

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Source

Identifiers

PMID: 18980857
DOI: 10.1016/j.parkreldis.2008.09.004

Genes

TFAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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