Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial transcription factor A (TFAM) gene variation in Parkinson's disease.

Neuroscience letters - 13 Feb 2008

Alvarez Victoria, Corao Ana I, Sánchez-Ferrero Elena, De Mena Lorena, Alonso-Montes Cristina, Huerta Cecilia, Blázquez Marta, Ribacoba René, Guisasola Luis M, Salvador Carlos, García-Castro Mónica, Coto Eliecer

Abstract excerpt

Mitochondrial function is necessary to supply the energy required for cell metabolism. Mutations/polymorphisms in mitochondrial DNA (mtDNA) have been implicated in Parkinson's disease (PD). The mitochondrial transcription factor A (TFAM) controls the transcription of mtDNA and regulates the mtDNA-copy number, thus being important for maintaining ATP production. TFAM dysfunction may also be involved in PD, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Energy Metabolism

Share to Mitochondrial Proteins

Share to Mutation, Missense

Share to Parkinson Disease

Share to Risk Factors

Share to Transcription Factors

Source

Identifiers

PMID: 18248889
DOI: 10.1016/j.neulet.2007.12.010

Genes

TFAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial transcription factor A (TFAM) gene variation in Parkinson's disease.PMID 18248889Read ↗

Parkinson's Disease, Parkinsonisms, and Mitochondria: the Role of Nuclear and Mitochondrial DNA.Semantic proximity Read ↗

Mitochondrial transcription factor A variants and the risk of Parkinson's disease.Semantic proximity Read ↗

Association of a polymorphism in mitochondrial transcription factor A (TFAM) with Parkinson's disease dementia but not dementia with Lewy bodies.Semantic proximity Read ↗

Mutational screening of the mitochondrial transcription factors B1 and B2 (TFB1M and TFB2M) in Parkinson's disease.Semantic proximity Read ↗

Association study of two genetic variants in mitochondrial transcription factor A (TFAM) in Alzheimer's and Parkinson's disease.Semantic proximity Read ↗

Parkinson's disease and mitochondrial gene variations: a review.Semantic proximity Read ↗

Possible association of mitochondrial transcription factor A (TFAM) genotype with sporadic Alzheimer disease.Semantic proximity Read ↗

Mitochondrial DNA in Parkinson's disease.Semantic proximity Read ↗

Mitochondrial DNA variants, haplogroups and risk of Parkinson's disease: A systematic review and meta-analysis.Semantic proximity Read ↗

Mitochondrial transcription factor A (TFAM) gene variation and risk of late-onset Alzheimer's disease.Semantic proximity Read ↗

Sequence analysis of the entire mitochondrial genome in Parkinson's disease.Semantic proximity Read ↗

ATP13A2 variability in Parkinson disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.