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Article

Inhibition of TRPM8 by icilin distinct from desensitization induced by menthol and menthol derivatives.

The Journal of biological chemistry - 13 Feb 2009

Kühn Frank J P, Kühn Cornelia, Lückhoff Andreas

Abstract excerpt

TRPM8 is a cation channel activated by cold temperatures and the chemical stimuli menthol and icilin. Both compounds use different mechanisms of current activation; amino acid residues within the S2-S3 linker have been identified critical for current activation by icilin but not by menthol. Curre...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19095656
DOI: 10.1074/jbc.M806651200

Genes

TRPM8
TRPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19095656-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Inhibition of TRPM8 by icilin distinct from desensitization induced by menthol and menthol derivatives.PMID 19095656Read ↗

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Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison.Semantic proximity Read ↗

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Importance of a conserved sequence motif in transmembrane segment S3 for the gating of human TRPM8 and TRPM2.Semantic proximity Read ↗

Surface expression and channel function of TRPM8 are cooperatively controlled by transmembrane segments S3 and S4.Semantic proximity Read ↗

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