Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors.

European journal of pharmacology - 28 Jan 2009

Lotito Luca, Russo Alessandra, Bueno Susana, Chillemi Giovanni, Fogli Maria Vittoria, Capranico Giovanni

Abstract excerpt

Topoisomerase I (Top1) is the specific target of the anticancer drug camptothecin (CPT) that interferes with enzyme activity promoting Top1-mediated DNA breaks and inhibition of DNA and RNA synthesis. To define the specific transcriptional response to CPT, we have determined the CPT-altered trans...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Camptothecin
Share to Cell Cycle
Share to DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Topoisomerases, Type I

Share to Down-Regulation

Share to Gene Regulatory Networks

Share to Genes, Fungal

Share to Up-Regulation

Source

Identifiers

PMID: 19094980
DOI: 10.1016/j.ejphar.2008.12.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19094980-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors.PMID 19094980Read ↗

Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: activation of telomere-proximal genes by TOP1 deletion.Semantic proximity Read ↗

The role of TDP1 from budding yeast in the repair of DNA damage.Semantic proximity Read ↗

Molecular and genetic analysis of the toxic effect of RAP1 overexpression in yeast.Semantic proximity Read ↗

A novel mutation in DNA topoisomerase I of yeast causes DNA damage and RAD9-dependent cell cycle arrest.Semantic proximity Read ↗

Nonclassic Functions of Human Topoisomerase I: Genome-Wide and Pharmacologic AnalysesSemantic proximity Read ↗

A Yeast-Based Screening System for Differential Identification of Poison Inhibitors and Catalytic Inhibitors of Human Topoisomerase ISemantic proximity Read ↗

Yeast mutants as a model system for identification of determinants of chemosensitivity.Semantic proximity Read ↗

Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.Semantic proximity Read ↗

Alterations in the catalytic activity of yeast DNA topoisomerase I result in cell cycle arrest and cell death.Semantic proximity Read ↗

Increased camptothecin toxicity induced in mammalian cells expressing Saccharomyces cerevisiae DNA topoisomerase I.Semantic proximity Read ↗

Topoisomerase II regulates yeast genes with singular chromatin architectures.Semantic proximity Read ↗

Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.