Article

A Yeast-Based Screening System for Differential Identification of Poison Inhibitors and Catalytic Inhibitors of Human Topoisomerase I

2021-11-16

Abstract excerpt

1. <h4>ABSTRACT</h4> Inhibition of human topoisomerase I (TOP1) by camptothecin and topotecan has been shown to reduce excessive transcription of PAMP (Pathogen-Associated Molecular Pattern) - induced genes in prior studies, preventing death from sepsis in animal models of bacterial and SARS-CoV-2 infections. The TOP1 catalytic activity likely resolves the topological constraints on DNA that encodes these genes t...

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Literature Corpus work: 7ada9d25-6750-5657-a970-72bf653ae3ec
DOI: 10.1101/2021.11.16.468530

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