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Article

Increased camptothecin toxicity induced in mammalian cells expressing Saccharomyces cerevisiae DNA topoisomerase I.

The Journal of biological chemistry - 3 Apr 1998

Hann C, Evans D L, Fertala J, Benedetti P, Bjornsti M A, Hall D J

Abstract excerpt

The yeast Saccharomyces cerevisiae has been useful in establishing the phenotypic effects of specific mutations on the enzymatic activity and camptothecin sensitivity of yeast and human DNA topoisomerase I. To determine whether these phenotypes were faithfully reiterated in higher eukaryotic cells, wild-type and mutant yeast Top1 proteins were epitope-tagged at the amino terminus and transiently overexpressed in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 9525954
DOI: 10.1074/jbc.273.14.8425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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