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Article

The transcription factor EBF1 non-cell-autonomously regulates cardiac growth and differentiation

3 Oct 2023

Abstract excerpt

Reciprocal interactions between non-myocytes and cardiomyocytes regulate cardiac growth and differentiation. Here, we report that the transcription factor Ebf1 is highly expressed in non-myocytes and potently regulates heart development. Ebf1-deficient hearts display myocardial hypercellularity and reduced cardiomyocyte size, ventricular conduction system hypoplasia, and conduction system disease. Growth...

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PMID: 37787076
DOI: 10.1242/dev.202054

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