Article
Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1.
Oncogene - 15 Aug 2002
Zhang Yuexing, Fondell Joseph D, Wang Qianben, Xia Xianmin, Cheng Aiwu, Lu Michael L, Hamburger Anne W
Abstract excerpt
Members of the ErbB family of receptors have been implicated in regulation of androgen receptor (AR) activity. Ebp1, an ErbB-3 binding protein recently cloned in our laboratory, possesses an LXXLL motif important in mediating interactions with nuclear hormone receptors. Therefore, we sought to determine if Ebp1 could bind AR and influence AR transcriptional activation potential. We demonstrate in this study that...
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