Article
Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases.
Nucleic acids research - 15 Apr 2003
Zhang Yuexing, Woodford Nicholas, Xia Xianmin, Hamburger Anne W
Abstract excerpt
Ebp1, an ErbB3 binding protein that is a member of the proliferation-associated PA2G4 family, inhibits the proliferation and induces the differentiation of human ErbB positive breast and prostate cancer cell lines. Ebp1 binds the tumor suppressor retinoblastoma protein (Rb) both in vivo and in vitro, and Rb and Ebp1 cooperate to inhibit the transcription of the E2F1-regulated cyclin E promoter. We show here that...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Binding Sites
- Butyrates
- COS Cells
- Carrier Proteins
- Cell Cycle Proteins
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor
- Enzyme Inhibitors