Article
Ebp1, an ErbB‐3 binding protein, interacts with Rb and affects Rb transcriptional regulation
9 Mar 2001
Abstract excerpt
Ebp1, an ErbB-3 binding protein, inhibits the proliferation and induces the differentiation of human breast cancer cells. The mechanisms of these effects are unknown. Rb, the product of the retinoblastoma gene, is an important modulator of cell cycle progression and cellular differentiation. We report that Rb is a binding target for Ebp1. Ebp1 was localized to both the nucleus and the cytoplasm of logarithmically...
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