Article
An interleukin 1 beta point mutant demonstrates that jun/fos expression is not sufficient for fibroblast metalloproteinase expression.
The Journal of biological chemistry - 5 Sept 1991
Conca W, Auron P E, Aoun-Wathne M, Bennett N, Seckinger P, Welgus H G, Goldring S R, Eisenberg S P, Dayer J M, Krane S M
Abstract excerpt
Substitution of glycine for arginine at position 127 of the mature human interleukin 1 beta protein generates a mutant IL-1 beta protein (IL-1 beta R----G) which binds cellular IL-1 receptors with high affinity but fails to elicit significant proliferation of T-helper cells (Gehrke, L., Jobling, S. A., Paik, L. S. K., McDonald, B., Rosenwasser, L. J., and Auron, P. E. (1990) J. Biol. Chem. 265, 5922-5925)....
Topics
- Blotting, Northern
- Cells, Cultured
- DNA-Binding Proteins
- Fibroblasts
- Gene Expression Regulation, Enzymologic
- Humans
- Interleukin-1
- Kinetics
- Metalloendopeptidases
- Mutation