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Article

The pro domain of pre-pro-transforming growth factor beta 1 when independently expressed is a functional binding protein for the mature growth factor.

Biochemistry - 24 Jul 1990

Gentry L E, Nash B W

Abstract excerpt

Transforming growth factor beta 1 (TGF-beta 1) is proteolytically derived from the carboxyl terminus of a 390 amino acid precursor molecule termed pre-pro-TGF-beta 1. Previous studies have suggested that the pro piece of pre-pro-TGF-beta 1 may play an important role in the formation of an inactive, latent complex. These latent forms are thought to be important in the regulation of TGF-beta 1 activity. To...

Topics

Animals
Base Sequence
Binding Sites
Carrier Proteins
DNA
Gene Expression
Molecular Sequence Data
Mutation
Protein Conformation
Protein Precursors
Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transforming Growth Factor beta

Transforming Growth Factors

Source

Identifiers

PMID: 2397217
DOI: 10.1021/bi00481a014

Genes

CGA
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2397217-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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