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Article

Synthetic alleles at position 121 define a functional domain of human interleukin-1 beta.

European journal of biochemistry - 1 Jun 1996

Ambrosetti D C, Palla E, Mirtella A, Galeotti C, Solito E, Navarra P, Parente L, Melli M

Abstract excerpt

The non-conservative substitution of the tyrosine residue at position 121 of human interleukin-1 beta (IL-1 beta) generates protein mutants showing strong reduction of the capacity to induce (a) prostaglandin E2 (PGE2) release from fibroblasts and smooth muscle cells, (b) murine T-cells proliferation and (c) activation of interleukin-6 (IL-6) gene expression. It is generally accepted that these functions are...

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PMID: 8681939
DOI: 10.1111/j.1432-1033.1996.0308z.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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