Synthetic alleles at position 121 define a functional domain of human interleukin-1 beta.

doi:10.1111/j.1432-1033.1996.0308z.x

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Article

Synthetic alleles at position 121 define a functional domain of human interleukin-1 beta.

European journal of biochemistry - 1 Jun 1996

Ambrosetti D C, Palla E, Mirtella A, Galeotti C, Solito E, Navarra P, Parente L, Melli M

Abstract excerpt

The non-conservative substitution of the tyrosine residue at position 121 of human interleukin-1 beta (IL-1 beta) generates protein mutants showing strong reduction of the capacity to induce (a) prostaglandin E2 (PGE2) release from fibroblasts and smooth muscle cells, (b) murine T-cells prolifera...

Topics

Alleles
Animals
Binding Sites
Binding, Competitive
Cell Division
Cell Line
Dinoprostone
Fever
Gene Expression Regulation
Humans
Hypothalamus
Interleukin-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-6

Lymphocyte Activation

Male

Mice

Mice, Inbred C3H

Point Mutation

Source

Open in PubMed

Identifiers

PMID: 8681939
DOI: 10.1111/j.1432-1033.1996.0308z.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8681939-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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