Article
Role of activator protein-1 on the effect of arginine-glycine-aspartic acid containing peptides on transforming growth factor-beta1 promoter activity.
The international journal of biochemistry & cell biology - 1 Jan 2007
Ruiz-Torres M P, Perez-Rivero G, Diez-Marques M L, Griera M, Ortega R, Rodriguez-Puyol M, Rodríguez-Puyol D
Abstract excerpt
While arginine-glycine-aspartic acid-based peptidomimetics have been employed for the treatment of cardiovascular disorders and cancer, their use in other contexts remains to be explored. Arginine-glycine-aspartic acid-serine induces Transforming growth factor-beta1 transcription in human mesangial cells, but the molecular mechanisms involved have not been studied extensively. We explored whether this effect...
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