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Article

Polymorphisms in the SHBG gene influence serum SHBG levels in women with polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism - 1 Apr 2011

Wickham Edmond P, Ewens Kathryn G, Legro Richard S, Dunaif Andrea, Nestler John E, Strauss Jerome F

Abstract excerpt

CONTEXT: Single-nucleotide polymorphisms (SNPs) in the SHBG gene are associated with type 2 diabetes mellitus. SHBG has also been proposed as a candidate gene for the polycystic ovary syndrome (PCOS). OBJECTIVE: The study aims were 1) to determine whether any of four SHBG SNPs (rs1779941, rs6297, rs6259, and rs727428) are associated with PCOS and 2) to determine whether SNP genotype influences SHBG levels in PCOS...

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Topics

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Share to Diabetes Mellitus, Type 2
Share to DNA Copy Number Variations
Share to Glucose Intolerance
Share to Insulin Resistance
Share to Obesity
Share to Polycystic Ovary Syndrome
Share to Serum
Share to Sex Hormone-Binding Globulin

Source

Open in PubMed Open full text

Identifiers

PMID: 21252242
DOI: 10.1210/jc.2010-1842
PMCID: PMC3070246

Genes

SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Polymorphisms in the SHBG gene influence serum SHBG levels in women with polycystic ovary syndrome.PMID 21252242Read ↗

Common Variants in the Sex Hormone-Binding Globulin (SHBG) Gene Influence SHBG Levels in Women with Polycystic Ovary Syndrome.Semantic proximity Read ↗

Sex hormone-binding globulin genetic variation: associations with type 2 diabetes mellitus and polycystic ovary syndrome.Semantic proximity Read ↗

Association of anthropometric, androgenic and insulin-related features with polymorphisms in exon 8 of SHBG gene in women with polycystic ovary syndrome.Semantic proximity Read ↗

Common variants in the sex hormone-binding globulin gene (SHBG) and polycystic ovary syndrome (PCOS) in Mediterranean women.Semantic proximity Read ↗

Association of the Genetic Polymorphisms rs6259 and rs727428 of the SHBG Gene with Polycystic Ovary Syndrome Risk: A Meta-Analysis.Semantic proximity Read ↗

Association between human SHBG gene polymorphisms and risk of PCOS: a meta-analysis.Semantic proximity Read ↗

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes.Semantic proximity Read ↗

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The (TAAAA)n microsatellite polymorphism in the SHBG gene influences serum SHBG levels in women with polycystic ovary syndrome.Semantic proximity Read ↗

Genetic variants of sex hormone-binding globulin and their biological consequences.Semantic proximity Read ↗

The relationship of sex hormone-binding globulin (SHBG) gene polymorphisms with serum SHBG level and metabolic syndrome in Chinese Han males.Semantic proximity Read ↗

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