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Article

Energetics of calmodulin domain interactions with the calmodulin binding domain of CaMKII.

Proteins - 1 Jul 2009

Evans T Idil Apak, Shea Madeline A

Abstract excerpt

Calmodulin (CaM) is an essential eukaryotic calcium receptor that regulates many kinases, including CaMKII. Calcium-depleted CaM does not bind to CaMKII under physiological conditions. However, binding of (Ca(2+))(4)-CaM to a basic amphipathic helix in CaMKII releases auto-inhibition of the kinase. The crystal structure of CaM bound to CaMKIIp, a peptide representing the CaM-binding domain (CaMBD) of CaMKII,...

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Identifiers

PMID: 19089983
DOI: 10.1002/prot.22317
PMCID: PMC2924166

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