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Article

Disruption of interdomain interactions via partial calcium occupancy of calmodulin.

Biochemistry - 17 Apr 2007

Boschek Curt B, Squier Thomas C, Bigelow Diana J

Abstract excerpt

Binding of calcium to CaM exposes clefts in both N- and C-domains to promote their cooperative association with a diverse array of target proteins, functioning to relay the calcium signal regulating cellular metabolism. To clarify relationships between the calcium-dependent activation of individual domains and interdomain structural transitions associated with productive binding to target proteins, we have...

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PMID: 17378588
DOI: 10.1021/bi6025402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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