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Article

Computational design of calmodulin mutants with up to 900-fold increase in binding specificity.

Journal of molecular biology - 6 Feb 2009

Yosef Eliyahu, Politi Regina, Choi Mee H, Shifman Julia M

Abstract excerpt

Calmodulin (CaM) is a ubiquitous second messenger protein that regulates a variety of structurally and functionally diverse targets in response to changes in Ca(2+) concentration. CaM-dependent protein kinase II (CaMKII) and calcineurin (CaN) are the prominent CaM targets that play an opposing role in many cellular functions including synaptic regulation. Since CaMKII and CaN compete for the available Ca(2+)/CaM,...

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Source

Identifiers

PMID: 18845160
DOI: 10.1016/j.jmb.2008.09.053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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