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Article

Calcium regulation of calmodulin binding to and dissociation from the myo1c regulatory domain.

Biochemistry - 23 Oct 2007

Manceva Slobodanka, Lin Tianming, Pham Huy, Lewis John H, Goldman Yale E, Ostap E Michael

Abstract excerpt

Myo1c is an unconventional myosin involved in cell signaling and membrane dynamics. Calcium binding to the regulatory-domain-associated calmodulin affects myo1c motor properties, but the kinetic details of this regulation are not fully understood. We performed actin gliding assays, ATPase measurements, fluorescence spectroscopy, and stopped-flow kinetics to determine the biochemical parameters that define the...

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Identifiers

PMID: 17910470
DOI: 10.1021/bi700894h
PMCID: PMC2566900

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Source receipt: pubmed, retrieved 7 Sept 2026.

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