Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A common variant in the MTNR1b gene is associated with increased risk of impaired fasting glucose (IFG) in youth with obesity.

Obesity (Silver Spring, Md.) - 1 May 2015

Zheng Chao, Dalla Man Chiara, Cobelli Claudio, Groop Leif, Zhao Hongyu, Bale Allen E, Shaw Melissa, Duran Elvira, Pierpont Bridget, Caprio Sonia, Santoro Nicola

Abstract excerpt

OBJECTIVE: To explore the role of MTNR1B rs10830963 and G6PC2 rs560887 variants in the pathogenesis of impaired fasting glucose (IFG) in obese adolescents. METHODS: A total of 346 Caucasians, 218 African-Americans, and 217 Hispanics obese children and adolescents underwent an oral glucose tolerance test (OGTT) and 518 underwent the evaluation of insulin secretion by the oral minimal model (OMM). Also, 274...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Black or African American
Share to Blood Glucose
Share to Fasting
Share to Hispanic or Latino
Share to Insulin Secretion
Share to Pediatric Obesity
Share to Prediabetic State
Share to Receptor, Melatonin, MT2

Source

Open in PubMed Open full text

Identifiers

PMID: 25919927
DOI: 10.1002/oby.21030
PMCID: PMC4414047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A common variant in the MTNR1b gene is associated with increased risk of impaired fasting glucose (IFG) in youth with obesity.PMID 25919927Read ↗

Association of the rs10830963 polymorphism in MTNR1B with fasting glucose levels in Chinese children and adolescents.Semantic proximity Read ↗

Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function.Semantic proximity Read ↗

The MTNR1B Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjects.Semantic proximity Read ↗

MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans.Semantic proximity Read ↗

A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: genetic risk is modulated by obesity.Semantic proximity Read ↗

Variants in MTNR1B influence fasting glucose levels.Semantic proximity Read ↗

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.Semantic proximity Read ↗

Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism.Semantic proximity Read ↗

Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS.Semantic proximity Read ↗

G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans.Semantic proximity Read ↗

Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans.Semantic proximity Read ↗

The CDKN2A/B rs10811661 polymorphism is associated with metabolic syndrome, insulin resistance, and lipid levels in individuals with obesity and impaired fasting glucose.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.