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Article

A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: genetic risk is modulated by obesity.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Nov 2012

Been L F, Hatfield J L, Shankar A, Aston C E, Ralhan S, Wander G S, Mehra N K, Singh J R, Mulvihill J J, Sanghera D K

Abstract excerpt

Two common variants (rs1387153, rs10830963) in MTNR1B have been reported to have independent effects on fasting blood glucose (FBG) levels with increased risk to type 2 diabetes (T2D) in recent genome-wide association studies (GWAS). In this investigation, we report the association of these two variants, and an additional variant (rs1374645) within the GWAS locus of MTNR1B with FBG, 2h glucose, insulin resistance...

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Share to Blood Glucose
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Share to Receptor, Melatonin, MT2

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Identifiers

PMID: 21558052
DOI: 10.1016/j.numecd.2011.01.006
PMCID: PMC3155734

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Related research

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A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: genetic risk is modulated by obesity.PMID 21558052Read ↗

Effects of MTNR1B variants on fasting glucose levels in a Korean populationSemantic proximity Read ↗

Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function.Semantic proximity Read ↗

Association of the rs10830963 polymorphism in MTNR1B with fasting glucose levels in Chinese children and adolescents.Semantic proximity Read ↗

The MTNR1B Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjects.Semantic proximity Read ↗

A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals.Semantic proximity Read ↗

Variants in MTNR1B influence fasting glucose levels.Semantic proximity Read ↗

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.Semantic proximity Read ↗

A common variant in the MTNR1b gene is associated with increased risk of impaired fasting glucose (IFG) in youth with obesity.Semantic proximity Read ↗

Association of KCNB1 polymorphisms with lipid metabolisms and insulin resistance: a case-control design of population-based cross-sectional study in Chinese Han population.Semantic proximity Read ↗

Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population.Semantic proximity Read ↗

Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism.Semantic proximity Read ↗

Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.Semantic proximity Read ↗

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