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Article

The alpha 2A-adrenergic receptor gene polymorphism modifies antidepressant responses to milnacipran.

Journal of clinical psychopharmacology - 1 Oct 2008

Wakeno Masataka, Kato Masaki, Okugawa Gaku, Fukuda Tsuyoshi, Hosoi Yuka, Takekita Yoshiteru, Yamashita Megumi, Nonen Shinpei, Azuma Junichi, Kinoshita Toshihiko

Abstract excerpt

OBJECTIVE: The alpha 2A-adrenergic receptor (ADRA2A) plays a central role in the regulation of systemic sympathetic activity. Recently, the functional defect of ADRA2A has been implicated as a cause of depression, attention deficit hyperactivity disorder, and Tourette syndrome. In this study, the effect of genetic variants of the ADRA2A gene on the response to selective serotonin reuptake inhibitors...

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Share to Receptors, Adrenergic, alpha-2

Source

Identifiers

PMID: 18794646
DOI: 10.1097/JCP.0b013e31818455fc

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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