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Article

Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility.

Genes and immunity - 1 Oct 2009

Márquez A, Cénit M C, Núñez C, Mendoza J L, Taxonera C, Díaz-Rubio M, Bartolomé M, Arroyo R, Fernández-Arquero M, de la Concha E G, Urcelay E

Abstract excerpt

Genome-wide studies highlighted the effect in Crohn's disease (CD) and ulcerative colitis (UC) susceptibility of single nucleotide polymorphisms (SNPs) in 3p21, where BSN (bassoon), MST1 (macrophage stimulating-1) and MST1R (MST1 Receptor) genes map. MST1R expression was significantly downregulated in multiple sclerosis (MS) compared with control brains, resembling findings in the MS mouse model. We pursued to...

Topics

Adult
Alleles
Animals
Colitis, Ulcerative
Crohn Disease
Gene Frequency
Genetic Predisposition to Disease
Genotype
Haplotypes
Hepatocyte Growth Factor
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Multiple Sclerosis

Nerve Tissue Proteins

Polymorphism, Single Nucleotide

Proto-Oncogene Proteins

Spain

Source

Identifiers

PMID: 19657358
DOI: 10.1038/gene.2009.56

Genes

MST1
BSN
MST1R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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