Article
Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility.
Genes and immunity - 1 Oct 2009
Márquez A, Cénit M C, Núñez C, Mendoza J L, Taxonera C, Díaz-Rubio M, Bartolomé M, Arroyo R, Fernández-Arquero M, de la Concha E G, Urcelay E
Abstract excerpt
Genome-wide studies highlighted the effect in Crohn's disease (CD) and ulcerative colitis (UC) susceptibility of single nucleotide polymorphisms (SNPs) in 3p21, where BSN (bassoon), MST1 (macrophage stimulating-1) and MST1R (MST1 Receptor) genes map. MST1R expression was significantly downregulated in multiple sclerosis (MS) compared with control brains, resembling findings in the MS mouse model. We pursued to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
