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Article

Transgenic mice bearing a human mutant thyroid hormone beta 1 receptor manifest thyroid function anomalies, weight reduction, and hyperactivity.

Molecular medicine (Cambridge, Mass.) - 1 May 1997

Wong R, Vasilyev V V, Ting Y T, Kutler D I, Willingham M C, Weintraub B D, Cheng S

Abstract excerpt

BACKGROUND: Resistance to thyroid hormone (RTH) is a syndrome characterized by refractoriness of the pituitary and/or peripheral tissues to the action of thyroid hormone. Mutations in the thyroid hormone receptor beta (TR beta) gene result in TR beta 1 mutants that mediate the clinical phenotype by interfering with transcription of thyroid hormone-regulated genes via a dominant negative effect. In this study, we...

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PMID: 9205946
PMCID: PMC2230075

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