Article
Transgenic mice bearing a human mutant thyroid hormone beta 1 receptor manifest thyroid function anomalies, weight reduction, and hyperactivity.
Molecular medicine (Cambridge, Mass.) - 1 May 1997
Wong R, Vasilyev V V, Ting Y T, Kutler D I, Willingham M C, Weintraub B D, Cheng S
Abstract excerpt
BACKGROUND: Resistance to thyroid hormone (RTH) is a syndrome characterized by refractoriness of the pituitary and/or peripheral tissues to the action of thyroid hormone. Mutations in the thyroid hormone receptor beta (TR beta) gene result in TR beta 1 mutants that mediate the clinical phenotype...
Topics
- Animals
- Body Weight
- Brain
- Cloning, Molecular
- Deoxyribonuclease HindIII
- Disease Models, Animal
- Hyperkinesis
- Immunohistochemistry
- Liver
- Mice
- Mice, Transgenic
- Mutation
- Plasmids
- RNA, Messenger
- Receptors, Thyroid Hormone