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Article

Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism.

Molecular endocrinology (Baltimore, Md.) - 1 Jun 2004

Rabeler Roland, Mittag Jens, Geffers Lars, Rüther Ulrich, Leitges Michael, Parlow Albert F, Visser Theo J, Bauer Karl

Abstract excerpt

To provide an animal model of central hypothyroidism, mice deficient in the TRH-receptor 1 (TRH-R1) gene were generated by homologous recombination. The pituitaries of TRH-R1-/- mice are devoid of any TRH-binding capacity, demonstrating that TRH-R1 is the only receptor localized on TRH target cells of the pituitary. With the exception of some retardation in growth rate, TRH-R1-/- mice appear normal, but compared...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14988432
DOI: 10.1210/me.2004-0017

Genes

TRH
PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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