Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mice lacking the thyrotropin-releasing hormone gene: what do they tell us?

Thyroid : official journal of the American Thyroid Association - 1 Dec 2003

Yamada Masanobu, Satoh Tetsurou, Mori Masatomo

Abstract excerpt

Thyrotropin-releasing hormone (TRH) is localized in the brain hypothalamus and stimulates the secretion and synthesis of pituitary thyrotropin (TSH). Although TRH deficiency caused by artificial hypothalamic destructions has been reported to result in significant decreases in TSH secretion in rodents, clinical observations from the patients with possible TRH deficiency did not entirely agree with these animal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic and Fetal Development
Share to Hormone Replacement Therapy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hypothyroidism

Share to Peptides, Cyclic

Share to Pituitary Gland, Anterior

Share to Protein Precursors

Share to Thyrotropin

Share to Thyroxine

Source

Identifiers

PMID: 14751031
DOI: 10.1089/10507250360731505

Genes

TRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mice lacking the thyrotropin-releasing hormone gene: what do they tell us?PMID 14751031Read ↗

Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism.Semantic proximity Read ↗

Requirement of thyrotropin-releasing hormone for the postnatal functions of pituitary thyrotrophs: ontogeny study of congenital tertiary hypothyroidism in mice.Semantic proximity Read ↗

Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior.Semantic proximity Read ↗

Insight into the physiological actions of thyroid hormone receptors from genetically modified mice.Semantic proximity Read ↗

Dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis.Semantic proximity Read ↗

Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin.Semantic proximity Read ↗

TRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes.Semantic proximity Read ↗

Behavioural phenotyping of male growth hormone-releasing hormone (GHRH) knockout mice.Semantic proximity Read ↗

Thyroid hormones and the central nervous system of mammals (Review)Semantic proximity Read ↗

An unliganded thyroid hormone receptor causes severe neurological dysfunctionSemantic proximity Read ↗

Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function.Semantic proximity Read ↗

Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.