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Article

Dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis.

The Journal of biological chemistry - 24 Feb 2006

Nikrodhanond Amisra A, Ortiga-Carvalho Tania M, Shibusawa Nobuyuki, Hashimoto Koshi, Liao Xiao Hui, Refetoff Samuel, Yamada Masanobu, Mori Masatomo, Wondisford Fredric E

Abstract excerpt

Hypothalamic thyrotropin-releasing hormone (TRH) stimulates thyroid-stimulating hormone (TSH) secretion from the anterior pituitary. TSH then initiates thyroid hormone (TH) synthesis and release from the thyroid gland. Although opposing TRH and TH inputs regulate the hypothalamic-pituitary-thyroid axis, TH negative feedback is thought to be the primary regulator. This hypothesis, however, has yet to be proven in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16339138
DOI: 10.1074/jbc.M511530200

Genes

TRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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