A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice.

Abstract excerpt

Thyroid hormone has profound effects on metabolic homeostasis, regulating both lipogenesis and lipolysis, primarily by modulating adrenergic activity. We generated mice with a point mutation in the thyroid hormone receptor alpha (TRalpha) gene producing a dominant-negative TRalpha mutant receptor with a proline to histidine substitution (P398H). The heterozygous P398H mutant mice had a 3.4-fold (p < 0.02)...

Topics

• Adipose Tissue
• Animals
• Blotting, Western
• Body Weight
• Carrier Proteins
• Catecholamines
• Cold Temperature
• Dose-Response Relationship, Drug
• Electrocardiography
• Female
• Genes, Dominant