Amino acid residues required for physical and cooperative transcriptional interaction of STAT3 and AP-1 proteins c-Jun and c-Fos.

doi:10.1128/MCB.00613-07

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Article

Amino acid residues required for physical and cooperative transcriptional interaction of STAT3 and AP-1 proteins c-Jun and c-Fos.

Molecular and cellular biology - 1 Sept 2007

Ginsberg Michael, Czeko Elmar, Müller Patrick, Ren Zhiyong, Chen Xiaomin, Darnell James E

Abstract excerpt

Cooperation between STAT3 and c-Jun in driving transcription during transfection of reporter constructs is well established, and both proteins are present on some interleukin-6 (IL-6) STAT3-dependent promoters on chromosomal loci. We report that small interfering RNA knockdown of c-Jun or c-Fos diminishes IL-6 induction of some but not all STAT3-dependent mRNAs. Specific contact sites in STAT3 responsible for...

Topics

Amino Acid Sequence
Animals
Carcinoma, Hepatocellular
Cell Line, Tumor
Glutathione Transferase
Humans
Interleukin-6
Liver Neoplasms
Molecular Sequence Data
Mutation
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Protein Structure, Tertiary

Proto-Oncogene Proteins c-fos

Proto-Oncogene Proteins c-jun

RNA, Messenger

RNA, Small Interfering

Rats

Source

Open in PubMed Open full text

Identifiers

PMID: 17636030
DOI: 10.1128/MCB.00613-07
PMCID: PMC2099614

Genes

STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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