Article
Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.
Molecular and cellular biology - 1 Aug 1992
Smeal T, Binetruy B, Mercola D, Grover-Bardwick A, Heidecker G, Rapp U R, Karin M
Abstract excerpt
In resting cells, c-Jun is phosphorylated on five sites. Three of these sites reside next to its DNA binding domain and negatively regulate DNA binding. In response to expression of oncogenic Ha-Ras, phosphorylation of these sites decreases, while phosphorylation of two other sites within c-Jun's activation domain is greatly enhanced. Phosphorylation of these residues, serines 63 and 73, stimulates the...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- Electrophoresis, Polyacrylamide Gel
- Methionine
- Mice
- Mutation
- Oncogene Protein p21(ras)
- Oncogene Protein pp60(v-src)