Article
v-Jun represses c-jun proto-oncogene expression in vivo through a 12-O-tetradecanoylphorbol-13-acetate-responsive element in the proximal gene promoter.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Aug 1998
Hussain S, Kilbey A, Gillespie D A
Abstract excerpt
c-jun proto-oncogene expression is extinguished in cells transformed by v-Jun; however, the mechanistic basis of this phenomenon has not been elucidated. c-jun mRNA levels are greatly reduced in v-Jun-transformed cells, and we show that this reduction is associated with a similar decrease in the...
Topics
- Activating Transcription Factors
- Animals
- Blood Proteins
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line, Transformed
- Chick Embryo
- Cyclic AMP Response Element-Binding Protein
- DNA-Binding Proteins
- Down-Regulation
- Fibroblasts
- Gene Expression Regulation
- Genes, jun
- JNK Mitogen-Activated Protein Kinases