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Article

New evidence of association between COMT gene and prefrontal neurocognitive function in healthy individuals from sibling pairs discordant for psychosis.

The American journal of psychiatry - 1 Jun 2004

Rosa Araceli, Peralta Víctor, Cuesta Manuel J, Zarzuela Amalia, Serrano Fermín, Martínez-Larrea Alfredo, Fañanás Lourdes

Abstract excerpt

OBJECTIVE: Using a sample of sibling pairs discordant for psychosis, the authors attempted to replicate the findings of previous studies suggesting that the functional genetic polymorphism Val158Met in the catechol O-methyltransferase (COMT) gene influences prefrontal cognitive function and increases the risk for schizophrenia. METHOD: Eighty-nine sibling pairs discordant for psychosis were genotyped for this...

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Source

Identifiers

PMID: 15169701
DOI: 10.1176/appi.ajp.161.6.1110

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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New evidence of association between COMT gene and prefrontal neurocognitive function in healthy individuals from sibling pairs discordant for psychosis.PMID 15169701Read ↗

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Influence of genetic variability at the COMT gene on TMT-B performance in psychotic patients and their healthy siblings.Semantic proximity Read ↗

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Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.Semantic proximity Read ↗

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The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons.Semantic proximity Read ↗

Prefrontal neurons and the genetics of schizophrenia.Semantic proximity Read ↗

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