Article
Structural and functional analyses of the DMC1-M200V polymorphism found in the human population.
Nucleic acids research - 1 Jul 2008
Hikiba Juri, Hirota Kouji, Kagawa Wataru, Ikawa Shukuko, Kinebuchi Takashi, Sakane Isao, Takizawa Yoshimasa, Yokoyama Shigeyuki, Mandon-Pépin Béatrice, Nicolas Alain, Shibata Takehiko, Ohta Kunihiro, Kurumizaka Hitoshi
Abstract excerpt
The M200V polymorphism of the human DMC1 protein, which is an essential, meiosis-specific DNA recombinase, was found in an infertile patient, raising the question of whether this homozygous human DMC1-M200V polymorphism may cause infertility by affecting the function of the human DMC1 protein. In...
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