Article
Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias.
Blood - 15 Feb 2002
Gombart Adrian F, Hofmann Wolf-K, Kawano Seiji, Takeuchi Seisho, Krug Utz, Kwok Scott H, Larsen Renee J, Asou Hiroya, Miller Carl W, Hoelzer Dieter, Koeffler H Phillip
Abstract excerpt
The CCAAT/enhancer binding protein alpha (C/EBPalpha) protein is essential for proper lung and liver function and granulocytic and adipose tissue differentation. It was hypothesized that abnormalties in C/EBPalpha function contribute to the development of malignancies in a variety of tissues. To...
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