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Article

G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation.

Blood - 15 Nov 2003

Allende Maria L, Yamashita Tadashi, Proia Richard L

Abstract excerpt

Sphingosine-1-phosphate (S1P) stimulates signaling pathways via G-protein-coupled receptors and triggers diverse cellular processes, including growth, survival, and migration. In S1P1 receptor-deficient embryos, blood vessels were incompletely covered by vascular smooth muscle cells (VSMCs), indicating the S1P1 receptor regulates vascular maturation. Because S1P1 receptor expression is not restricted to a...

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Share to Blood Vessels
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelium, Vascular

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Share to Muscle, Smooth, Vascular

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Share to Receptors, G-Protein-Coupled

Source

Identifiers

PMID: 12869509
DOI: 10.1182/blood-2003-02-0460

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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