Article
A G protein mutant that inhibits thrombin and purinergic receptor activation of phospholipase A2.
Science (New York, N.Y.) - 10 Aug 1990
Gupta S K, Diez E, Heasley L E, Osawa S, Johnson G L
Abstract excerpt
The stimulation of phospholipase A2 by thrombin and type 2 (P2)-purinergic receptor agonists in Chinese hamster ovary cells is mediated by the G protein Gi. To delineate alpha chain regulatory regions responsible for control of phospholipase A2, chimeric cDNAs were constructed in which different...
Topics
- Adenosine Triphosphate
- Animals
- Arachidonic Acid
- Arachidonic Acids
- Cell Line
- Chlorides
- Enzyme Activation
- GTP-Binding Proteins
- Inositol Phosphates
- Kinetics
- Lithium
- Lithium Chloride
- Macromolecular Substances
- Mutation
- Phospholipases
- Phospholipases A
- Phospholipases A2
- Receptors, Purinergic