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Article

A G protein mutant that inhibits thrombin and purinergic receptor activation of phospholipase A2.

Science (New York, N.Y.) - 10 Aug 1990

Gupta S K, Diez E, Heasley L E, Osawa S, Johnson G L

Abstract excerpt

The stimulation of phospholipase A2 by thrombin and type 2 (P2)-purinergic receptor agonists in Chinese hamster ovary cells is mediated by the G protein Gi. To delineate alpha chain regulatory regions responsible for control of phospholipase A2, chimeric cDNAs were constructed in which different lengths of the alpha subunit of Gs (alpha s) were replaced with the corresponding sequence of the Gi alpha subunit...

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PMID: 2166341
DOI: 10.1126/science.2166341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A G protein mutant that inhibits thrombin and purinergic receptor activation of phospholipase A2.PMID 2166341Read ↗

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