Article
Chromosome substitution strains: a new way to study genetically complex traits.
Methods in molecular medicine - 1 Jan 2006
Hill Annie E, Lander Eric S, Nadeau Joseph H
Abstract excerpt
Many biological traits and heritable diseases are multifactorial, involving combinations of genetic variants and environmental factors. To dissect the genetic basis for these traits and to characterize their functional consequences, mouse models are widely used, not only because of their genetic and physiological similarity to humans, but also because an extraordinary variety of genetic resources enable rigorous...
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