Article
Genetic dissection of complex traits with chromosome substitution strains of mice.
Science (New York, N.Y.) - 16 Apr 2004
Singer Jonathan B, Hill Annie E, Burrage Lindsay C, Olszens Keith R, Song Junghan, Justice Monica, O'Brien William E, Conti David V, Witte John S, Lander Eric S, Nadeau Joseph H
Abstract excerpt
Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes. Here, we report the construction of a complete CSS panel for a vertebrate species. The CSS panel consists of 22 mouse strains, each of which carries a single chromosome substituted from a donor strain (A/J) onto a common...
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