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Article

Elevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6(-/-) small intestinal epithelium.

Oncogene - 10 Oct 2002

Mark Sean C, Sandercock Linda E, Luchman H Artee, Baross Agnes, Edelmann Winfried, Jirik Frank R

Abstract excerpt

The DNA mismatch repair (MMR) system is primarily responsible for purging newly synthesized DNA of errors incurred during semi-conservative replication. Lesion recognition is initially carried out by one of two heterodimeric protein complexes, MutS(alpha) or MutS(beta). While the former, comprised of MSH2 and MSH6, recognizes mispairs as well as short (1-2 nucleotide) insertions/deletions (IDLs), the latter, made...

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Share to Base Pair Mismatch
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12370835
DOI: 10.1038/sj.onc.1205861

Genes

MSH2
MSH3
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Elevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6(-/-) small intestinal epithelium.PMID 12370835Read ↗

Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum.Semantic proximity Read ↗

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Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability.Semantic proximity Read ↗

Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine.Semantic proximity Read ↗

Oxidative Stress Accelerates Repeat Instability and Base Substitutions, Promoting Gastrointestinal Driver Mutations under MSH2 DeficiencySemantic proximity Read ↗

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Mutation in the mismatch repair gene Msh6 causes cancer susceptibility.Semantic proximity Read ↗

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