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Article

Oct4A is expressed by a subpopulation of prostate neuroendocrine cells

3 Dec 2008

Abstract excerpt

BACKGROUND: Cancer stem cells are defined by their self-renewal and multi-potential capabilities and are hypothesized to be the source of primary and recurrent cancers. The stem cell properties of self-renewal and pluripotency in embryonic stem cells and germ cells are regulated by Oct4A, a splice variant of the POU5F1 (Oct3/4) gene, while the function of the alternative splice variant, Oct4B, is unknown. Rare...

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PMID: 19058139
DOI: 10.1002/pros.20895

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